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Analysis

A spinal cuff reads the body as a magnetic field flips a gene switch

A flexible cuff read movement, sensory and organ signals from rodent spinal cords; a magnetic field switched on gene expression in mice. ULTRA’s three-dimensional scans separated glioma margins in human tissue better than flat sections. All remain early-stage.

Science··Midday
Gloved hands wrap a flexible electrode cuff around a transparent spinal-cord model, with a coil apparatus and a violet tissue volume in the background.

A wraparound cuff reads several spinal signals at once

A Houston Methodist and University of Cambridge team described an ultrathin flexible electrode array that wraps all the way around the spinal cord in a peer-reviewed Nature Communications paper. The array conforms without penetrating neural tissue and, in freely moving rats during short-term implantation of up to three days, read intended movement, several kinds of sensory input and visceral sensory signals through the same interface. Deep-learning decoders reached R² = 0.97 for motor-intent decoding by exploiting low-frequency spinal oscillations aligned with central pattern generator rhythms; the same interface classified eight sensory modalities with 94.4 per cent accuracy. Cross-species checks in acutely anaesthetized pigs distinguished visceral sensory inputs. The design aims to bypass an injured segment rather than repair it. Everything so far is preclinical: the team tested rodents and larger anatomical models, says the next step is restoring function in animals with chronic injury before any human trial, and no patient has been implanted.[2]

A magnetic field flips a gene switch in mice

A group led by Prof. Jongpil Kim at Dongguk University reported in a peer-reviewed Cell paper a gene switch driven by the Lgr4 promoter that responds to an electromagnetic field of 2.0 millitesla at 60 hertz. Expression returns to baseline within 24 hours once the field is switched off. The molecular sensor Cyb5b produces rhythmic calcium influx under the field, and aiming the field at part of the body produced localised expression in specific organs. A strong green fluorescent protein signal throughout the body confirmed the switch was working before the localised tests. Reported assays are in mice, transgenic animals included: an Alzheimer's model, partial cellular reprogramming in aged animals, and control of the Tph2 gene that raised serotonin and reduced depression-like behaviour. None of that has been tried in people.[3]

ULTRA separates human glioma margins in three dimensions

A Cell study led from Fudan University with Huashan Hospital and other Chinese centres combined tissue clearing, stimulated Raman microscopy and AI-based staining into a platform called ULTRA. It images about 1 cubic millimetre of brain tissue in three dimensions in 30 minutes. In samples from 17 patients, a three-dimensional classifier reached an AUC of 0.965, against 0.909 when the same volume was read as a single flat section. Pathologists reading a single flat section from the same volume missed tumour in 20–23 per cent of cases. The work develops and validates a method and does not measure clinical outcomes; the authors list slow deep-learning processing, uneven resolution along the depth axis, tissue-specific tuning and limited equipment access as constraints.[1]

References

  1. News sourceMedical XpressA 30-minute scan maps where a glioma really ends↩
  2. News sourceMedical XpressA cuff around the spinal cord reads movement, touch and organ signals at once↩
  3. News sourcePhys.orgA magnetic-field switch turns genes on in mice and lets go within a day↩