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EGFR T790M shows a 60-fold lung-cancer link in never-smokers

Dana-Farber Cancer Institute and 23andMe Research Institute linked inherited EGFR T790M to a 25-fold higher lung-cancer risk overall and to more than 60-fold among people who never smoked. Live Science’s feed said the rare mutation raises risk in nonsmokers and is more common among people born in Southeastern US states.

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Bright genetics laboratory scene with an anonymous technician pipetting into a DNA sample rack while lung CT images glow on a light-box behind the bench.

Twenty-five fold, sixty fold

Dana-Farber Cancer Institute and 23andMe Research Institute linked inherited EGFR T790M to a 25-fold higher lung-cancer risk overall, and to more than 60-fold among people who never smoked. The 17 September institute note is the retained news account of that association. It does not, in the sentences used here, walk through laboratory steps. The numbers 25 and 60 are the association figures the institute published.[1], [2]

Smokers still show a gap

Among people who smoked, carriers were about 10 times as likely to develop lung cancer as noncarriers. The institute note says that relative figure does not mean smoking is protective. Investigators compared people with and without lung cancer, and analysed never-smokers separately. Those comparison lines are outcomes in the news release, not a hospital protocol. The 10-times gap sits beside the 60-fold never-smoker line.[1], [2]

Southeastern US births in the feed

Live Science’s own feed said scientists identified a rare genetic mutation that dramatically raises lung-cancer risk in nonsmokers. The RSS lede said the mutation was much more common among people born in Southeastern US states than elsewhere. The full page did not yield a complete body under ordinary fetch. However the Dana-Farber note already names EGFR T790M and the 25 / 60 / 10 figures. Alternative explanation: a regional birth pattern reflects ancestry clustering rather than a local environmental origin.[1], [2]

References

  1. News sourceDana-Farber Cancer InstituteEGFR T790M carries a 60-fold lung-cancer association in never-smokers↩1↩2↩3
  2. News sourceLive Sciencea rare mutation raises lung-cancer risk in nonsmokers↩1↩2↩3