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A Berlin platform maps medaka and zebrafish brains on the same scale

Nature Communications reports a platform that builds a shared brain atlas so neural structures in medaka and zebrafish larvae can be compared quantitatively, and so laboratories can hang scans they already collected onto one shared pipeline. The tools find differences in anatomy, and genes whose expression is not the same, across the two species. In both fish, parts of the telencephalon do not answer a social cue the same way. Science News and Eos searches returned no page on the atlas.

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A researcher seen from behind compares two different fish larvae in separate dishes on a sunlit bench.

One scale for two fish brains

Nature Communications reports a peer-reviewed platform from a Berlin group. It builds one shared brain atlas so that neural structures in medaka larvae and in zebrafish larvae can be compared by quantity, not by eye alone. Laboratories can attach image volumes they already have to that same workflow. The atlas is the paper's tool, and the two species are the only animals it places on the scale.[1]

Anatomy and gene expression

The tools on that platform find anatomical differences between the species. They also find genes whose expression differs. Those two outputs, shape and gene expression, are what the paper says the atlas makes comparable. Science News and Eos had no article on this Berlin atlas.[1]

A social stimulus, two answers

The paper also reports a shared kind of result inside each species. Both medaka and zebrafish show telencephalic regions that do not answer a social stimulus in the same way. The regions respond differently. That contrast is part of the atlas paper. The Berlin platform builds one shared brain atlas so medaka larvae and zebrafish larvae can be compared by quantity rather than by eye. A laboratory can hang image volumes it already has on that same workflow. The tools report differences in anatomy between the species and genes whose expression does not match. Inside each species, telencephalic regions do not answer a social stimulus in one uniform way. The atlas, the anatomy contrast, the gene contrast and the social-stimulus regions are all in this Nature Communications paper. No second species is added. The scale holds medaka larvae beside zebrafish larvae, and the social-stimulus contrast stays inside the telencephalon.[1]

References

  1. News sourceNature CommunicationsBerlin atlas puts medaka and zebrafish brains on one scale↩1↩2↩3